Assoc. Prof. Jiří Kofránek M.D.
Future Forces Forum
Head of Laboratory of Biocybernetics
1st Faculty of Medicine, Charles University
PHYSIOMODEL – Large Scale Integrated Model of Human Physiology as a Core of a Sophisticated Medical Simulators
Models used as the theoretical foundation of sophisticated medical simulators must include mathematical models not only of individual physiological subsystems, but also their interconnections, thus forming a more complex unit. We have designed the large-scale integrative model of human physiology PHYSIOMODEL (www.physiomodel.org) as the reimplementation and extension of model HumMod 1.6 from Mississippi University (www.hummod.org). Our extensions in acid-base and blood gases transport improve the usability of the model during the modeling of complex disorders of acid-base, ionic, volume and osmotic homeostasis, which is very important for urgent medicinal statuses. The PHYSIOMODEL is an Open Source model written in Modelica language. Modelica is a new computer language that enables to create a transparent and legible model structure and therefore offers easier model modifications and extensions. The PHYSIOMODEL was used for our project “Virtual Patient”, where many theoretical scenarios can be simulated with a virtual environment like a computer game.
Since 1966 he was main researcher of many research and development grants (see http://patf-biokyb.lf1.cuni.cz/wiki/wiki/user/seznam_projektu). His research deals with mathematical modeling of physiological systems. He is founder of Laboratory of Biocybernetics, where he created a multidisciplinary team of physicians, mathematicians, computer scientists and artists (creating a user interface simulation models). His research deals with mathematical modeling of physiological systems. He is author or co-author more than 400 publications (see list of publications: http://patf-biokyb.lf1.cuni.cz/wiki/wiki/user/seznam_publikaci, see google profile: http://scholar.google.cz/citations?user=Qv8pd7MAAAAJ&hl=en). University Teacher: 1st Faculty of Medicine, Charles University: “Pathophysiology” Faculty of Electrical Engineering, Czech Technical University: “Modeling and Simulation” (Doc. Kofránek has also Associated Professor of Technical Cybernetics). Present Position: Department of pathophysiology, 1st Faculty of Medicine, Charles University, Associated Professor, Head of Laboratory of Biocybernetics.